Priligy (dapoxetine hydrochloride) is the first oral medication approved for the treatment of premature ejaculation. It was a coincidence that they discovered that it was able to treat premature ejaculation, which was actually developed to treat depression. In this electronic resource (electronic source) we use the history of Viagra to show how a drug is developed and manufactured.Dapoxetine hydrochloride as an active ingredient in Priligy belongs to the class of drugs called selective inhibitors of serotonin reuptake (SSRI) A short half-life of 1 or 2 hours is considered safe for the treatment of premature ejaculation. During the initial development of dapoxetine, some sources attributed it to Eli Lilly's chemist David Wong, who was also one of the developers of fluoxetine (Prozac). Like Prozac and other antidepressants like Zoloft, Escitalopram and Paxil, dapoxetine is an SSRI. Given the early development of the drug over a decade ago, Eli Lilly started phase I clinical trials for dapoxetine as an antidepressant. But dapoxetine was suspended for a while and was not considered an antidepressant. However, the same thing that led to his failure as a psychopharmaceutical has proven to be the reason for his success in treating premature ejaculation.
Dapoxetine as SRRI
Similar to other SSRIs, dapoxetine delays ejaculation and orgasm, and for some time now doctors have been prescribing other SSRIs to treat premature ejaculation. However, because these antidepressants are not approved by the FDA to treat this condition, this is considered an "off-label" use. In contrast to other SSRIs, dapoxetine is easily and quickly absorbed and excreted by the body, ie within hours instead of days. It was Karl Thor, a researcher from Eli Lilly, who recognized the potential of the drug as a treatment, especially for premature ejaculation. Due to its short time in the body, it is considered an anti-depressant as impracticable. On the other hand, it is more suitable for treating premature ejaculation. Eli Lilly has repeated several attempts with the drug, but this time to treat premature ejaculation.
Who owns Dapoxetine Priligy?
Patents and rights to appeal have changed occasionally and some pharmaceutical companies have rights to dapoxetine. The drug was developed by Eli Lilly, but in 1998 PPD GenuPro acquired the rights to Eli Lilly to develop the drug for the treatment of premature ejaculation. In 2001, however, PPD sold the exclusive worldwide rights to commercialize and develop dapoxetine to a Johnson & Johnson subsidiary, ALZA Corporation. In 2003, PPD acquired patents for dapoxetine from Eli Lilly. PPD continues to receive milestone payments and royalties for medicines from ALZA, even if ALZA is the current licensee. However, if the PPD exceeds a certain amount, Eli Lilly may receive royalties. Today Dapoxetine is marketed by Janssen-Ortho Inc. in Canada, Ortho McNeil in the USA and currently by Janssen-Cilag in Europe. all are units of Johnson & Johnson, why is Priligy (dapoxetine) a safe medicine?Eli Lilly conducted the first clinical studies with dapoxetine (phase I) that were approved by the FDA. Phase II studies are being carried out in collaboration with PPD GenuPro. PPD presented the results of two main studies in 2005 after the phase III studies continued. Men aged 18-65 years were given doses of 60 mg or 100 mg of dapoxetine, which increased the ejaculation time. In 2008, dapoxetine was tested on more than 6,000 subjects in five large phase III studies. It was found that dapoxetine not only increases intravaginal ejaculation latency, but also improves overall sexual satisfaction and the feeling of ejaculation control overwork. In 2009 it was approved in Sweden, Finland, Austria, Portugal, Germany, Italy and Spain. Approvals are also expected in other European countries. Applications for approval have also been made in Canada, Australia, Mexico, Turkey and six other countries.
Become the envy of men - discover natural techniques for premature ejaculation that you can use at home!
Premature ejaculation is very common these days. It rarely occurs due to physical or neurological problems in the body. It can be associated with mental health problems, especially anxiety and performance debt. This problem can also be permanent and last a lifetime. In addition, it is always associated with emotional upheavals and a decline in interpersonal relationships. There is a strong loss of confidence that is not healthy for your sex life in the long run.
There are many men who do not know whether they have this problem or not. The best way to diagnose is to check the patient's sexual history. With this diagnosis, the patient is asked about the sexual history so that the therapist can identify the actual problem. The main issue is what information should be included. The therapist must receive appropriate information from both the patient and his partner without hurting his deep feelings.
Another method is to use premature ejaculation exercises. Through these exercises, we can strengthen the muscles of your PC so that you have more control over when you have fun. There are cases where the cause of the unfortunate problem lies in the partner's body composition. The partner's genitals may have a structure that is not comfortable for the male genitals, and for this reason the male partner reaches the climax much earlier. There may be a reason for premature ejaculation, and it is very important to find the right reason for the cure.
PDE-5 inhibitor - Viagra
Take care of nature for the best treatment for depression - The best treatment for depression has been at the center of the debate for some time. While most physicians focus on the use of traditional medicines, patients and their families who are unhappy with the serious side effects and addictiveness of these medicines have looked for other answers. Now there are other promising treatments.