Antidepressant Therapy Based on Melatonin Receptors in the USA?
Self-medication is not the best way to treat a severe form of depression. Various natural psychoactive compounds are generally used in this potentially harmful practice. These compounds range from alcohol to over-the-counter products, including the hormone melatonin. Hormone therapies are best suited to replace pathologically low or missing endogenous hormone levels. The use of insulin to treat diabetes is a good example. It is difficult to make a simple and convincing case for using melatonin replacement therapy - too many miracle cures have been linked to melatonin. Perhaps the best use of this hormone is to regulate sleep patterns or prevent jet lag. But could melatonin be therapeutic for diseases like severe depression? There are no clinical data that clearly demonstrate the use of melatonin in antidepressant therapy. However, clinical results suggest that melatonin receptors may be involved.
A search for clinical trials with melatonin in the US government sponsored database on June 7, 2011 resulted in 128 trials. Most of these studies were designed to examine the effects of melatonin supplementation on sleep. None of them have studied melatonin supplementation to treat depression. One study measured melatonin levels in the blood of patients with severe depression, and some studies looked at the effects of light therapy for depression and measured melatonin levels in the subjects treated. This is in stark contrast to the number of clinical trials with a drug that stimulates melatonin receptors, a target that is thought to be specific for the cellular effects of melatonin. The compound in question, agomelatine, is approved in Europe for the treatment of depression and is currently being investigated in Australia.
How would melatonin receptors alleviate the symptoms of severe depression? Imagine for a moment that you have just won a huge Mega Millions jackpot and bought a villa. It is a huge lock with many doors, each with at least one lock and some with several. These locks are the melatonin receptors. There are two main types of these receptors, MT1 and MT2. They also have the master key, melatonin, which unlocks both types of locks. To the parents-in-law who went there as soon as they heard of your wealth, only give the keys for certain locks, the MT1 or the MT2, so that you can keep some privacy. For the special room in which you store your most valuable items, you have an additional security layer, a door that is not only equipped with MT1 and MT2 locks, but also with an unusual lock, the serotonin receptor called 5-HT2C. To open this door, the 5-HT2C lock must be locked at the same time that you use the master key to unlock the MT1 and MT2 locks. What a job!
Apparently, you can do the same with your brain's 5-HT2C, MT1, and MT2 receptors by taking agomelatine, a drug that works simultaneously on the MT1 and MT2 melatonin receptors (as an agonist) and acts as a 5-HT2C serotonin receptor (as their antagonist). Scientists believe that this simultaneous manipulation of the melatonin and serotonin 5-HT2C brain receptors reduces the symptoms of severe depression. According to this concept, the use of melatonin alone would not have the same effect.
In her article, The Model of Melatonin Receptor Expression in the Brain Can Affect Antidepressant Treatment, Dr. Eric Hirsch-Rodriguez and colleagues in the Department of Psychiatry at the University of Illinois at Chicago on how the presence is melatonin receptors like MT1 and MT2 in different regions of the brain change over time and can be affected by disease and drug therapy. For example, prolonged treatment with conventional antidepressants changes the levels of MT1 and MT receptors. These researchers suggested that melatonin or melatonin-based drugs would only produce antidepressant effects if an optimal amount and brain distribution of melatonin receptors were available for drug response and clinical trials with such drugs, should take into account the characterization of patients' melatonin receptors. ,
Agomelatine, the first antidepressant based on melatonin receptors, is currently being clinically tested and approved in Australia. On June 7, 2011, 9 clinical trials (one of which was withdrawn) were performed with agomelatine. Seven of these studies looked at the use of agomelatine in the treatment of depression. Their results and experience of continued use of agomelatine in Europe could determine the future of melatonin receptor therapy to improve the health of American patients with severe depression.
Depressive? Self-help kits work wonders, while antidepressants do more harm than good
Do you feel too sad over time? You may be clinically depressed. If so, what kind of help should you seek?
Your first reaction is likely to go to the doctor. And his first answer is likely to be prescribing antidepressants. After all, American doctors have prescribed 189 million antidepressants in just one year.
But here's the really depressing news: antidepressants don't work and can have terrible side effects. The side effects are undeniable, as pharmaceutical companies must label them on the packaging to protect you and all other consumers who ingest them.
Some patients benefit from it. However, drug manufacturers are still trying to make us believe that they really work for everyone. In fact, a new study published in the New England Journal of Medicine shows that drug manufacturers only publish their studies that prove the benefits of drugs, not those that don't.
As a practicing psychotherapist, this scares me because depression is one of the most common health problems in America and some even suggest that it could soon be the second cause of disabilities in this country. If drug manufacturers only publish their positive results, consumers' opinions about them will be distorted.
This would make patients believe they work for everyone, although in reality they may not be better than a placebo for most people. This fraudulent practice has fueled the consumption of psychiatric drugs as they are now the second class of drugs sold.
Antidepressants are a great source of income for pharmaceutical companies
Depression means big profits for shareholders. After all, women up to 25% more often suffer from severe depression and men up to 12%.
Antidepressants throw money on pharmaceutical manufacturers and their shareholders. Consumption of these drugs has tripled in the past 10 years and their expenditure has increased by 130% in just one year. In 2008, Americans spent no less than $ 12 billion there each year.
The New England Journal of Medicine study cited above shows that these drugs are often no more effective than a placebo. In fact, they can be very harmful due to the potential for terrible side effects.
Because antidepressants can be popular, that doesn't mean they're helpful. Unfortunately, as we now see from research, they often do not work and can have harmful side effects that affect the patient's quality of life.
Studies show that antidepressants:
- ... trigger a possibly fatal irregular heartbeat.
- ... cause abnormal retention of a patient's urine.
- ... dry the patient's mouth.
- ... increases a patient's risk of suicide.
- ... numb the patient's feelings.
In fact, 86 percent of patients taking antidepressants report one or more side effects. These include sexual dysfunction, fatigue, insomnia, loss of mental performance, nausea and weight gain.
New generation self-therapy kits (STKs) can alleviate your depressive symptoms with virtually no side effects
Self-therapy kits (STK) are compact self-help units that contain a powerful therapeutic punch. They are numerous and can include: CDs, DVDs, MP3s, e-books, folders, audios, videos, etc.
They are used in the privacy of your home and at your own pace. It is like having your own therapist who is available around the clock.
They use up-to-date information, visualizations, behavioral exercises and the simple monitoring of feelings and progress to make your symptoms disappear once and for all. There are no side effects, prescriptions, or problems visiting your doctor.
It is best to start them before you go for advice, because they can finally completely eliminate your symptoms. However, if you are currently in a consultation, concomitant use can significantly reduce the time it takes for your symptoms to go away.
Using a STK during treatment will likely increase the speed and quality of your recovery many times over!
How do you find these powerful self-therapy kits (STK)? Just go online and search for "self help", "self improvement", "anxiety, self help depression" etc.
Read the brochures carefully and make sure that the contents of the SKT are absolutely guaranteed and that the guarantee can be triggered by a simple and problem-free process. STKs are proven, tested, easy to use and a bargain.
It couldn't be better!